TP53 and cancer: TP53 mutations are most frequently missense mutations concentrated in the DNA-binding domain between codons 125 and 300 and occur in almost all types of cancer, including pancreatic cancer, ovarian cancer, esophageal cancer, colorectal cancer, head and neck cancer, laryngeal cancer and lung cancer (Olivier et al., 2010; Peltonen et al., 2010; Mogi and Kuwano, 2011; Yurgelun et al., 2015; Silwal-Pandit et al., 2017; McCubrey et al., 2022).