METTL3 and colorectal cancer: Most importantly, M6A methylation regulators have been reported to be oncogenic in many studies, and their increased expression is closely related to the occurrence and development of various malignancies, including colorectal cancer, pancreatic cancer, hepatocellular carcinoma, ovarian cancer, and breast cancer (Tanabe et al., 2016; Zhang et al., 2017; Chen et al., 2019; Li J et al., 2019; Li T et al., 2019; Chang et al., 2020; Liu et al., 2020; Wang et al., 2020; Zhang et al., 2020; Cao et al., 2022).