Homozygous mutations in the PDX1 gene and other mutations that impair the functionality of the PDX1 protein during embryonic development cause pancreas agenesis in mice and humans and eventually lead to fatal perinatal hyperglycemia (Jonsson et al., 1994; Stoffers et al., 1997; Hui and Perfetti, 2002). Here, PDX1 is linked to Hyperglycemia.