TMEM45A, a transmembrane protein, which has been proposed as a biomarker of clear cell renal cell carcinoma (ccRCC), was also reported to be associated with chemoresistance in breast cancer and HCC cells (Flamant et al., 2012; Wrzesinski et al., 2015). This evidence concerns the gene TMEM45A and nonpapillary renal cell carcinoma.