To deeply investigate the clinical value of CSGs in HCC, we performed LASSO Cox regression analysis to identify five vital genes (PSRC1, SOCS2, TMEM45A, CCT5, and STC2) from 238 robust prognostic DECSGs, which were subsequently employed to construct the CSGscore risk signature as a scoring system for HCC prognostic prediction. The gene discussed is TMEM45A; the disease is hepatocellular carcinoma.