Ritchie et al. treated GSTP1 knockout mice and wild-type mice with benzopyrene, 3-methylcholanthrene, and urethane, respectively, and found that GSTP1 gene deletion increased the incidence of lung adenocarcinoma in mice exposed to these three compounds, respectively 8.3 times, 4.3 times and 8.7 times (Ritchie et al., 2007). Here, GSTP1 is linked to lung adenocarcinoma.