GSTM1 and non-small cell lung carcinoma: It has been reported that glutathione metabolism in brain metastases from NSCLC is regulated by glutathione peroxidase and glutathione S-transferase; among them, GPX4 and GSTM1 are overexpressed in BM subsets, and cause massive consumption of GSH in brain metastases of lung cancer (Liu et al., 2021).