Zou et al. finds that Interferon (IFNγ) secreted by CD8+ T cells and ATM activated by radiotherapy can synergistically inhibit SLC7A11 expression to limit cystine uptake by tumor cells, leading to reduced GSH synthesis and thus promoting lipid peroxidation and ferroptosis (Lang et al., 2019). The gene discussed is SLC7A11; the disease is neoplasm.