DIAPH2 and neoplasm: In the present study, we demonstrated that the mRNA expression level of DIAPHs were significantly higher in PAAD tumor tissues than that in normal pancreas tissues in the consensus databases of TCGA and GTEx, as well as that total DIAPH1 and DIAPH2 protein expression levels were higher in the primary cancers than those in normal tissues for PAAD in the CPTAC dataset.