HMGB1 and pancreatic adenocarcinoma: Immune checkpoint analysis showed that the expression of DIAPHs in PAAD was significantly and positively correlated with immune checkpoints such as CD276, lymphocyte activating 3 (LAG3), high mobility group box 1 (HMGB1), hepatitis A virus cellular receptor 2 (HAVCR2), and B and T lymphocyte associated (BTLA) (Figure 8E).