Analysis of the expression data of DIAPHs in different tumor tissues and normal tissues in the consensus datasets TCGA and GTEx showed that the expression levels of DIAPH1 and DIAPH3 were significantly higher in tumor tissues than in normal tissues across most of the tumors in TCGA database (Figures 1A,C), while the expression levels of DIAPH2 were significantly lower in tumor tissues than in normal tissues across different types of cancers (Figure 1B). The gene discussed is DIAPH2; the disease is cancer.