In our study, we found that TFs such as BCL3, CREB1, and FOXA1 (Supplementary Material S2) have been reported to accelerate the occurrence and development of cervical cancer (Zhao et al., 2016) (Li et al., 2015) (Yang et al., 2020); these may inhibit the transcriptional expression of CMTM6, while E2F4 and ELK1 (Supplementary Material S2) had the opposite effect (Gong et al., 2020) (Zhang et al., 2020). The gene discussed is CREB1; the disease is cervical carcinoma.