There are multiple risk factors affecting the development and progression of retinopathy of prematurity, including low birth weight, preterm gestational age, appearance, pulse, grimace, activity, and respiration (APGAR) score, and especially the use of supplemental oxygen, which causes downregulation of the vascular endothelial growth factor (VEGF) due to oxidative stress and death of endothelial cells, intraventricular hemorrhage, sepsis, blood transfusions, and most importantly, lack of timely screening [3]. The gene discussed is VEGFA; the disease is Sepsis.