In a study regarding LIPUS-mediated anti-inflammatory effects on myocarditis by Zheng et al., caveolin-1 was significantly activated, and p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) signaling were significantly suppressed, which demonstrated LIPUS treatment attenuated the aggressive inflammatory response in myocarditis by activating caveolin-1 and suppressing p38 MAPK/ERK signaling (Zheng et al., 2019). The gene discussed is MAPK14; the disease is myocarditis.