BRCA1 and breast carcinoma: As shown in Figure 2, the results of a large study (95,961 patients) published in 2017 (53) reports lower OR values for the association of breast cancer with all known pathogenic variants in either BRCA gene (OR = 5.9 for BRCA1, OR = 3.3 for BRCA2) than the proposed 4-variant PML risk test (OR = 8.7).