Table 4 shows the association results for the top four PML risk variants. Three of the four top variants in genes C8B, FCN2, and STXBP2 show no association with MS. All three had an OR of 1.0 and uncorrected genome-wide P values of 0.07–0.71. The fourth top variant (in the LY9 gene) is very rare in the general population (gnomAD 3.1 allele frequency = 0.000072) and has not been reported in the literature to be associated with disease (including MS). This evidence concerns the gene STXBP2 and progressive multifocal leukoencephalopathy.