In the further subgroup analysis by cancer type, we identified that H19 rs217727 mutation increased oral squamous cell carcinoma (OSCC) risk under all models (allele model: OR = 1.31, 95% CI = 1.14–1.50, p < 0.001; recessive model: OR = 1.67, 95% CI = 1.04–2.67, p = 0.034; dominant model: OR = 1.37, 95% CI = 1.16–1.60, p < 0.001; homozygous model: OR = 1.89, 95% CI = 1.19–2.99, p = 0.007; heterozygote model: OR = 1.27, 95% CI = 1.07–1.51, p = 0.005). Here, H19 is linked to oral cavity squamous cell carcinoma.