Stratification by cancer type identified that H19 rs2839698 mutation increased the risk of digestive system neoplasm under allele model (OR = 1.14, 95% CI = 1.01–1.30, p = 0.040); recessive model (OR = 1.31, 95% CI = 1.02–1.69, p = 0.03); and homozygous model (OR = 1.33, 95% CI = 1.03–1.74, p = 0.03). The gene discussed is H19; the disease is digestive system neoplasm.