In 2010, two studies on African Americans identified genetic variants, named G1 and G2 alleles, in the Apolipoprotein L1 (APOL1) gene associated with an increased risk of developing hypertension-attributed ESRD or FSGS (Genovese et al., 1979; Genovese et al., 2010). Here, APOL1 is linked to Hypertension.