STAT3 and Sepsis: Previous studies showed that the phosphorylation of STAT3 is associated with the development of skeletal muscle atrophy in various conditions, including burns (Corrick et al., 2015; Kashiwagi, et al., 2017; Pin et al., 2019), sepsis (Zanders et al., 2022), cancer (Bonetto, et al., 2011; Silva et al., 2015), degenerative muscle disease (Wada et al., 2017; Liang et al., 2018), immobilization (Huang, et al., 2020; Hirata et al., 2022), and chronic kidney diseases (Zhang et al., 2013).