Proteomic mass spectrometry analysis of salivary exosomes from human papillomavirus (HPV)-driven oropharyngeal cancer patients revealed significantly elevated aldolase, glyceraldehyde dehydrogenase-3-phosphate dehydrogenase (GAPDH), LDHA/B, phosphoglycerate kinase 1 (PGK1) and PKM1/2 (Tang et al., 2021). This evidence concerns the gene GAPDH and oropharynx cancer.