For example, nasopharyngeal carcinoma cell-derived sEVs can transform normal fibroblasts to a tumor-promoting phenotype by delivering latent membrane protein 1 (LMP1), which enhances glycolysis and inhibits mitochondrial oxidative phosphorylation via activation of the NF-κB pathway (Wu et al., 2020). The gene discussed is NFKB1; the disease is neoplasm.