Retinoblastoma-derived exosomes are enriched in multiple metabolic enzymes, including enolase 3 (ENO3), galactokinase-1 (GALK1), asparagine synthase (ASNS) and saccharopine dehydrogenase (SCCPDH) (Galardi et al., 2020). Here, GALK1 is linked to retinoblastoma.