Mutations in both alleles of LCAT gene lead to two syndromes namely, familial LCAT deficiency (FLD), and fish-eye disease (FED) which caused serious clinical symptoms included a decrease in HDL cholesterol level, apo A-I and apo A-II, a decrease in LDL cholesterol level and an increase in FC and apo E (Lucca et al., 2016). This evidence concerns the gene APOE and fish eye disease.