In this study, the keywords with the strongest citation bursts included “transgenic mice”, “activation”, “human plasma low density”, “hepatic lipase”, “serum lipid”, “identification”, “lipid peroxidation”, “scavenger receptor”, “oxidative stress”, “metabolic syndrome”, “high-density lipoprotein cholesterol “, “risk”, “disease”, “hdl-c level”, “mass spectrometry”, “cardiovascular disease”, “deficiency”, “lecithin: cholestterol acyltransferase”, “cholesterol metabolism”, “familial lcat deficiency”. The gene discussed is LIPC; the disease is metabolic syndrome.