MAPK8 and asthma: In the study on treatment of asthma, it can diminish the expression of IL-4, IL-5, IL-13, IL-17A, IgE, CCL5, and CCL11, inhibit NF-kB- and JNK-mediated inflammatory signaling, and reduce oxidative damage through decreasing the activity of ROS and increasing SOD (Yi et al., 2020).