Fructose-2,6-bisphosphatase 3 (PFKFB3) is a glycolytic activator, and PFKFB3 upregulation in peritumor-associated monocytes/macrophages in HCC promotes tumor progression via attenuation of the cytotoxic T lymphocyte response in tumor tissue using the PFKFB3/NF-κB/PD-L1 axis (Chen D.P et al., 2019). The gene discussed is NFKB1; the disease is neoplasm.