Recent studies have reported that shikonin and its analogs, flavonoid derivatives, 2,3-dithiocarbamate substituted naphthoquinones, benserazide, and Compounds 3 k and 10i, can act as inhibitors of PKM2 and inhibit aerobic glycolysis of tumor cells to exert anti-tumor effects (Zahra et al., 2020; Zhu et al., 2021). This evidence concerns the gene PKM and neoplasm.