At the same time, the expressions of the HF markers α-SMA and collagen-1, intracellular proteins CaM and CaMKII, and downstream-related proteins MMP-13, NF-κB, NFAT, and mRNA were significantly decreased after blocking with the specific inhibitors of KN93 and CaMKII-siRNA. The gene discussed is ACTA1; the disease is hydrops fetalis.