Inhibition of ASIC1a activity significantly reduced the levels of inflammatory factors such as IL-1 and IL-6 in the serum of rats with HF, decreased the protein expression of α-SMA, transformating growth factor betal (TGF-β1), nuclear factor kappa B(NF-κB), and collagen-I in liver tissue, and reduced the degree of HF. This evidence concerns the gene ACTA1 and hydrops fetalis.