Zhao et al. (2018) found that CaMKII has an important physiological regulatory function in human umbilical vein endothelial cells. After inhibition of its activity, endothelial cell proliferation was significantly reduced. Transient receptor potential channel 4 (trpv4) regulates the proliferation of oral squamous cell carcinoma (OSCC). Ca2+ enters cancer cells, activates CaMKII, regulates downstream AKT phosphorylation, and promotes the growth of OSCC cells (Fujii et al., 2020). This evidence concerns the gene CAMK2G and cancer.