Previous animal studies showed that C-reactive protein (CRP), white blood cell count (WBC), leukocyte factor 18 (IL-18), leukocyte factor 6 (IL-6), leukocyte factor 1 (IL-1β), monocyte chemotaxis protein-1 (MCP-1), tumor necrosis factor α (TNF-α) and macrophage inflammation protein-lα (MIP-lα) levels were significantly elevated in PCOS rats. This evidence concerns the gene TNF and polycystic ovary syndrome.