This study also analyzed the changes of Bax and Bcl-2 expression in PCOS rats with QUR administration, showing that the Bax expression level was significantly decreased and the Bcl-2 expression level were increased after QUR treatment, which inferred that changes in these apoptosis-related proteins after QUR administration alleviated HA in PCOS rats, ultimately increasing E2 concentration, and ovarian aromatase protein content, and leading to folliculogenesis and atresia decrease (Mahmoud et al., 2022). Here, BCL2 is linked to polycystic ovary syndrome.