Previous studies found that QUR (daily dose range from 15 to 100 mg/kg/d) for 28–30 days (Wang et al., 2017; Jahan et al., 2018; Neisy et al., 2019; Mihanfar et al., 2021; Zheng et al., 2022a) could significantly reduce blood glucose, serum insulin, HOMA-IR, cholesterol, TG, and LDL-C levels, and elevate HDL-C levels in letrozole- or DHEA-induced PCOS rats. The gene discussed is INS; the disease is polycystic ovary syndrome.