QUR also reversed the PCOS-induced alteration, and increased the levels of adiponectin, visfatin, and resistin in adipose, inferring that QUR may be a potential cause for active therapeutic effects in PCOS by regulating adipose tissue hormone release and energy balance through the expression levels involved in the AMPK and SIRT-1 axes (Mihanfar et al., 2021). The gene discussed is SIRT1; the disease is polycystic ovary syndrome.