CYP19A1 and polycystic ovary syndrome: This study also analyzed the changes of Bax and Bcl-2 expression in PCOS rats with QUR administration, showing that the Bax expression level was significantly decreased and the Bcl-2 expression level were increased after QUR treatment, which inferred that changes in these apoptosis-related proteins after QUR administration alleviated HA in PCOS rats, ultimately increasing E2 concentration, and ovarian aromatase protein content, and leading to folliculogenesis and atresia decrease (Mahmoud et al., 2022).