It is found that using different doses of QUR (ranged from 15 to 100 mg/kg) reduced LH, the LH/FSH ratio, T, and free T and SHBG levels equally well in letrozole-induced PCOS rats (Jahan et al., 2018; Mihanfar et al., 2021; Zheng et al., 2022a; Mahmoud et al., 2022). This evidence concerns the gene PLOD1 and polycystic ovary syndrome.