The significance of adenosine transport through ENT1 in the regulation of the interstitial adenosine level (and thereby in the adenosine-induced protective processes) is reflected by the repressed expression and activity of ENT1 during long-term ischemia (Choi and Berdis, 2012; Boswell-Casteel and Hays, 2017). Here, SLC29A1 is linked to ischemia.