CHI3L1 and allergic rhinitis: A high level of YKL-40 expression is found in nasal mucosa of patients with mild and moderate/severe allergic rhinitis (Pirayesh et al., 2020), which participates in mucosal remodeling in the nasal cavity, mediates the epithelial detachment of nasal mucosa, tissue edema and small vessel hyperplasia, and aggravating the symptoms of allergic rhinitis (Sanai et al., 1999; Kim et al., 2019).