TLR4 and allergic rhinitis: Toll-like receptor 4 (TLR4) binds to the corresponding ligands (HMGB1 and LPS et al.)to activate the relevant signaling pathway, resulting to the activation and translocation of NF-κB, which induces allergic rhinitis by mediating cytokine secretion (Sha et al., 2008; Lauriello et al., 2012; Cui et al., 2015; Radman et al., 2015; Haruna et al., 2019).