CD8A and allergic rhinitis: In a study by Qiu et al., they found that exosomes can be discovered in the patients with chronic atypical allergic rhinitis, and these exosomes containing microbial products and airborne antigens, which can influence DCs maturation and major histocompatibility class I (MHCI) production, thereby promoting antigen specific CD8+ T cell development, eventually this leads to allergic rhinitis (Qiu et al., 2011; Qiu et al., 2012).