For example, we recently found that genetic inactivation of A2AR attenuates pathologic angiogenesis in the development of retinopathy of prematurity, but it does not affect developmental angiogenesis in the mouse retina (Liu et al., 2010; Zhang et al., 2017; Zhang et al., 2022). The gene discussed is ADORA2A; the disease is retinopathy of prematurity.