Our findings proved that TJ-5 reduced the infiltration ratio of peripheral myeloid cells in the cerebral infarction area, increased the proportion of inactive microglia, and decreased the expression levels of TNF-α, IL-1β, and IL-6 in the infarction areas after 24 h of reperfusion, suggesting that TJ-5 may interrupt the inflammatory cascade and inhibit excessive neuroinflammation. Here, TNF is linked to cerebral infarction.