HMOX1 and metabolic dysfunction-associated steatotic liver disease: Therefore, the purpose of the current study was to determine whether naringin could ameliorate NAFLD progression induced by fructose feeding, and to evaluate the hypothesis that naringin inhibits the progression of NAFLD via regulating the DNL and G3P pathways, enhancing the Nrf2/HO-1 pathway and decreasing inflammatory cytokine production.