HMOX1 and hydrops fetalis: Figure 5A shows that DHE fluorescence intensity, an indicator of ROS, was higher in liver sections from HF group than in the control group, whereas naringin treatment attenuated the DHE fluorescence intensity to control levels. Western blot analysis revealed that fructose-fed rats showed a significant decrease in Nrf2 and HO-1 protein expression in the liver (p < 0.05, 0.01), whereas these proteins were significantly increased after naringin treatment (p < 0.05) (Figures 5B,C).