More specifically, compared to adjacent normal tissues, ATP7A, LIAS, LIPT1, LIPT2, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, CDKN2A and DLST was increased, whereas the expression of NLRP3, SLC31A1, and DBT was decreased in HCC. The gene discussed is PDHB; the disease is hepatocellular carcinoma.