By gene expression profiling, the results showed that ATP7A, LIAS, LIPT1, LIPT2, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, CDKN2A, and DLST were up-regulated, while NLRP3, SLC31A1, and DBT were down-regulated in HCC compared to adjacent normal tissues, which is consistent with previous studies. This evidence concerns the gene CDKN2A and hepatocellular carcinoma.