Furthermore, we found, by examining autophagy marker proteins (Beclin-1, LC3-II, and beclin-1) in the hearts of mice that underwent 5/6 nephrectomy and serum uremia-treated H9C2 cardiomyocytes, that supplementation with NaHS or L-Cys could decrease excessive autophagy activity. Here, BECN1 is linked to uremia.