STING1 and neoplasm: Ghaffari et al. (2018) announced that agonists of STING protein could reduce OC induced ascites formation and tumor aggressiveness. Furthermore, Poly (ADP-ribose) polymerase (PARP) inhibition enhances cytosolic DNA fragments accumulation and elicits antitumor responses in mice with BRCA1-deficient OC through STING-dependent pathway (Ding et al., 2018; Shen et al., 2019). In addition, Matthew Knarr et al. (2020) found that miR-181a promoted tumorigenesis in fallopian tube secretory epithelial cells through induction of genomic instability by simultaneously targeting RB1 and STING.