Furthermore, GS-Rd can be used as alternative drug therapy for AD patients in the prevention and treatment of their memory dysfunction (Liu et al., 2015), Ling Li et al. (Li et al., 2021) demonstrate that GS-Rd is capable of inhibiting the Aβ-induced tau phosphorylation by altering the functional balance of GSK-3β and CDK5/P25 in the olfactory bulb, spinal cord and telencephalon. Here, MAPT is linked to Alzheimer disease.