The KEGG pathway enrichment analysis also showed that the MAPK signaling pathway (Figure 7E), which is well-known to be implicated in AD, was significantly impacted, as well as that protein processing in the endoplasmic reticulum and transcription regulation in cancer play roles in AD, this strongly suggests that GS-Rd reduces the synthesis of Aβ through the MAPK pathway, thereby reducing Aβ deposition. Here, GSR is linked to Alzheimer disease.