This result fully reflects the complexity of the molecular mechanism of GS-Rd treatment of AD; the node pairs with a confidence value higher than 0.98 are listed in Table 1; HSP90AA1, JAK2, STAT3, GRB2, PTPN11, MAPK1 and EGFR exhibited significant interactions with other target proteins. This evidence concerns the gene JAK2 and Alzheimer disease.