In this study, CL2006 worms were used for heat resistance tests and the detection of anti-Aβ effects of GS-Rd; Paralysis experiments, Aβ mRNA level detection and RNA-seq studies were carried out to verify the mechanism of GS-Rd in treating AD; The CL4176 strain was also used to measure the levels of ROS and SOD to investigate why GS-Rd delayed worm paralysis. Here, SOD1 is linked to Alzheimer disease.