Curcumin, the yellow pigment considered one of the primary bioactive substance in Curcuma longa L., was tested at doses of 20, 40, and 80 mg/kg, and found to alleviate LPS induced sepsis and liver failure in rats by suppression of oxidative stress-related inflammation via phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) and NF-kB related signaling. This evidence concerns the gene NFKB1 and liver failure.