Moreover, in vivo study showed that acute administration of quercetin (1, 10, 50, or 100 mg/kg injected intraperitoneally) decreased the lethality rate and circulating levels of TNF-α and IL-1β in C57BL/6J mice with endotoxemia induced by LPS (Chang et al., 2013). Here, IL1B is linked to serum lipopolysaccharide activity.