Liu et al. (2022) also observed that Rg1, at 35 or 70 mg/kg injected intraperitoneally, activates the Akt/GSK-3β pathway through P2X purinoceptor 7 (P2X7) receptors to inhibit sepsis-induced cardiac dysfunction and mitochondrial dysfunction. This evidence concerns the gene P2RX7 and Sepsis.