TNF and Sepsis: Naringin (50 and 100 mg/kg administered by oral gavage) also protected against sepsis-induced myocardial dysfunction by significantly reducing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and myocardial enzymes including creatine kinase (CK), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) induced by LPS.