TLR4 and Sepsis: 6-Gingerol-treated mice also displayed lower mortality in polymicrobial sepsis induced by CLP by enhancing bacterial clearance in the peritoneum, blood, and organs (liver, spleen, and kidney) while also suppressing the generation of TNF-α and IL-6 in TLR2 and/or TLR4-stimulated macrophages (Ju et al., 2021).