COL18A1 and metastatic melanoma: Many studies showed Endostatin levels were closely associated with aggressive phenotypes or poor outcomes in various malignancies (Alahuhta et al., 2015; Chen et al., 2018; Zamaratskaia et al., 2020; Zhang et al., 2021a; Zhu et al., 2022), such as metastatic melanoma (Fukuda et al., 2011; Liang et al., 2018; Zhang et al., 2022).