Some critical functional enzymes and adhesion factors have been discussed in melanoma, including vascular endothelial growth factor A (VEGF-A), placental growth factor (PlGF), interleukin-8 (IL-8), primary fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF), angiopoietin (Ang), urokinase plasminogen activator (uPA), integrin, and MMPs (Singh et al., 2010; Laurenzana et al., 2017; Zhang et al., 2018a; Lacal and Graziani, 2018; Pekkonen et al., 2018; Zhang et al., 2019; Czarnecka et al., 2020; Ten Voorde et al., 2021). The gene discussed is PLAU; the disease is melanoma.