CDH1 and Alzheimer disease: APC/C-Cdh1 inactivation induces the accumulation of its target, glutaminase (Colombo et al., 2010), which in turn enhance glutamate levels and intracellular Ca2+ influx, creating a positive feedback loop of Cdh1 inactivation in AD (Fuchsberger et al., 2016) (Figure 1).