CDK5 and Alzheimer disease: Furthermore, oligomerized Aβ stimulates intracellular Ca2+ influx via the N-methyl-d-aspartate (NMDA)-type GluR, leading to Cdk5-p25 activation and Cdh1 phosphorylation (Lapresa et al., 2019; Maitra and Vincent 2022), then linking Cdh1 inactivation to AD pathology (Lapresa et al., 2019) (Figure 1).