ACE and leukodystrophy: SBP: systolic blood pressure; DBP: diastolic blood pressure; HR: heart rate; HTN: hypertension; DM: diabetes mellitus; HLD: hyperlipidemia; CHD: coronary heart disease; NYHA: New York Heart Association; ACEI: angiotensin-converting enzyme inhibitors; ARB: angiotensin receptor blockers; CCB: calcium channel blocker; MRA: mineralocorticoid receptor antagonist.