Interestingly, a comparison of ascending aortic wall specimens from AAD, aneurysms and normal controls by differential in-gel electrophoresis (DIGE) analysis revealed that antitrypsin (A1AT) was found to be reduced in protein amounts in aortic tissue from aortic dissection compared to healthy aorta, but not in aneurysms (138). Here, SERPINA1 is linked to aneurysm.