There are many similar rare mutations in common pathogenic genes, with the identification of heterozygous rare variants c.839G > T (p.Ser280Arg) (77) and c.893T > G (p.Met298Arg) (78) missense mutations in LOX, encoding a lysyl oxidase, leading to the development of ascending aortic dissection. The gene discussed is LOX; the disease is Ascending aortic dissection.