CDKN2A and aneurysm: Other genes, like the CDKN2A (cell cycle protein-dependent kinase inhibitor 2A) and CDKN2B genes on chromosome 9p21.3, which encode the senescence markers p16 and p15, have also been found to have genetic variations that have been linked to various vascular diseases and may contribute to aneurysm formation and aortic dissection (63).