Under ischemia-reperfusion injury (IRI), melanin restores the engagement of VDAC1 with hexokinase II (HKII) to restrict mitochondrial fission, which inhibits mPTP opening and PTEN induced kinase 1 (PINK1)/PARKIN activation, eventually blocking mitophagy-mediated cell death (53). This evidence concerns the gene PINK1 and ischemia reperfusion injury.