Variants of uncertain significance (VUS) were found in 17 cases (eight resuscitated and nine dead) in genes associated with HCM or dilated cardiomyopathy (DCM), such as TTN, TNNT2, MYH6, DSP, ACTN2, CALR3, and MYH7. The gene discussed is ACTN2; the disease is dilated cardiomyopathy.