After analysis of IRG expression characteristics in patients with different clinical features, we mainly focused on 5 IRGs (ITPR3, PDGFA, SLPI, TICAM1, and GATA4) that were associated with the grade, stage, and lymph node metastasis of the tumor, implying that they may exert important roles in EC progression. The gene discussed is GATA4; the disease is neoplasm.