CDKN2A and neoplasm: Figure 2(c) depicts the chromosomal location of CNV changes in the CRG. We next analyzed the mRNA expression levels of LC patients' tumor tissues and normal tissues and discovered that most CRG expression levels were inversely linked with CNV changes. CNV-depleted CRG, such as CDKN2A, were expressed at greater levels in LC tumor tissue samples than in normal lung samples, but CNV-raised CRG, such as NLRP3 and NFE2L2, was considerably enhanced in LC tumor tissue samples (Figure 2(d)), indicating that CNVs may control CRG mRNA expression.