The findings of univariate Cox regression and the Kaplan-Meier analysis indicated that nine CRG (MTF1, CDKN2A, ATP7A, DLD, LIPT1, SLC31A1, PDHB, DBT, and DLAT) had prognostic significance in LC patients (MTF1, CDKN2A, ATP7A, DLD, LIPT1, SLC31A1, PDHB, DBT, and DLAT) (Figure 2(a)). This evidence concerns the gene CDKN2A and laryngotracheoesophageal cleft.