Patients presenting with cardiac and renal disorders had the highest median NT‐proBNP levels (2069.0 pg/ml; range 136–19 833 pg/ml) compared to NT‐proBNP levels in those with cardiac disorders (425.0 pg/ml; range: 17–5768 pg/ml), those with renal disorders (265.1 pg/ml; 12–955), patients with other comorbidities (163.0 pg/ml; 0.5–15 930), and those without recorded comorbidities (1431 pg/ml; 1–1799) (p < .001). This evidence concerns the gene NPPB and kidney disorder.