Among them, four (CAR3, CD5L, GIMAP7, and TBC1D9) are novel to melanoma (Table 4), while CD5L, FCGR2B, IL33, and TNFRSF9 have direct roles in regulating immune reactions (see their mouse homologue genes in Additional file 24: Table S5a). The gene discussed is IL33; the disease is melanoma.