On the other hand, increases in granzyme B, granzyme C, perforin 1 and a set of MHC II locus expression also occurred in Q152H tumors (Tables 1 and 2); however, these tumors display no upregulation in immune checkpoints (Fig. 5c), implying an immunocompetent TME for Q152H tumors which may explain the Q152H-derived inhibition of tumor growth (Fig. 2e). Here, PRF1 is linked to neoplasm.