CYTH4, AOAH, DENND1C, TBC1D10C, EPSTI1, SERPINB8, and GIMAP7 are novel and robust individual genes in predicting resistance to ICB in multiple cancer types (Fig. 8; Additional file 7: Fig S7; Additional file 9: Fig S9; Additional file 12: Fig S12). The gene discussed is CYTH4; the disease is cancer.