In melanoma patients treated with CTLA4 or PD1 ICB, both Overlap36 and Overlap36sub stratify poor OS (Additional file 8: Fig S8a); among the 9 published signatures, Overlap36sub is the only one stratifying poor OS in clear cell renal cell carcinoma treated with ICB (Additional file 8: Fig S8b). Here, CTLA4 is linked to clear cell renal carcinoma.