This inhibitor is a racemic mixture and a cell-permeable pivaloyloxymethyl (POM) prodrug of HEX, which can selectively kill ENO1-deleted glioma cells at low-nanomolar concentrations and eradicate intracranial orthotopic ENO1-deleted tumors in mice at doses well-tolerated in non-human primates [56]. Here, ENO1 is linked to central nervous system cancer.