LAMB2 and metabolic dysfunction-associated steatohepatitis: Moreover, in high glucose-induced human liver sinusoidal endothelial cells (HLSECs) (an in vitro model of NAFLD), integrin αvβ3 antibody (clone LM609) significantly downregulated the expression of laminin and suppressed fibrosis.330 In fact, numerous studies have confirmed the efficacy of integrin αvβ3 as a predictor of fibrosis in experimental NASH models.325,328,331 However, no integrin αvβ3 inhibitors have been evaluated in clinical trials to investigate their inhibitory effect on the progression of NASH to liver fibrosis.