Integrins containing the αv subunit have received the most attention due to their activating activity on TGF-β, including αvβ1, αvβ5, αvβ6, and αvβ8.306,327 In addition, integrins α11 and RGD-recognizing integrins (such as αIIbβ3 and α5β1) are also important regulators of liver fibrosis.339 Integrin inhibitors such as IDL-2965 and PLN-74809 have been investigated in clinical trials to evaluate their therapeutic effect on liver fibrosis.339 However, none of their roles in fibrosis induced by NASH have been elucidated. This evidence concerns the gene IGKV3D-20 and Hepatic fibrosis.