Integrin αvβ3 and VEGF have a synergistic signaling connection during the activation of endothelial cells and vascularization induced by interplay between VEGF and ECM molecules.279 The anti-integrin αvβ3 antibody BV4 inhibits the phosphorylation of VEGFR2,279 and the VEGFR2-specific inhibitor SU1498 inhibits the complex interaction between VEGFR2 and integrin β3.280 FAK-Src signaling is important in both αvβ3 and VEGF-associated tumor angiogenesis.243 The crosstalk of integrin αvβ3 and VEGFR2 could be regulated by Src. This evidence concerns the gene VEGFA and neoplasm.