Knockout of integrin β7 (ITGB7) significantly promoted inflammatory cell infiltration and fibrosis in the livers of NASH mice.332 In contrast, MAdCAM-1 knockout showed anti-inflammatory activity.332 Later, integrin α4β7 was found to play an important role in the progression of NASH to liver fibrosis. This evidence concerns the gene MADCAM1 and metabolic dysfunction-associated steatohepatitis.