TGFB1 and renal fibrosis: Encouragingly, researchers have found that blocking the interaction between integrins (especially integrins rich in αv subunits) and TGF-β1 showed an efficient antifibrosis effect without causing TGF-β1 dysfunction-induced adverse effects.305 Integrins are receptors by which cells adhere to the ECM.312 Several integrins have been confirmed as activators of TGF-β1,312 and antagonists of αvβ154 and αvβ6313,314 have shown considerable inhibitory effects in experimental animal models of liver, lung, and renal fibrosis.