In addition, it has also been reported that anti-mouse osteopontin mouse IgG (35B6) inhibits the cell adhesion of mouse and human osteopontin to Chinese hamster ovary (CHO) cells expressing integrin α9, which suppresses liver inflammation and fibrosis in NASH mice.336 All these findings revealed the therapeutic potential of integrin α9β1 inhibitors in liver fibrosis induced by NASH. This evidence concerns the gene SPP1 and Hepatic fibrosis.