MADCAM1 and Hepatic fibrosis: The abnormality of gut microbiota in NASH mouse models promoted the expression of MAdCAM-1 in the liver, which recruited α4β7-positive CD4 T cells to the liver and induced inflammation and fibrosis.334 Blocking integrin α4β7 has shown promising therapeutic effects on fibrosis in NASH,334 indicating its great potential as a therapeutic target for NASH-induced liver fibrosis.