An AT1 blocker could promote the regression of cardiac hypertrophy by reducing integrin β1 expression.432 Moreover, a β3 integrin/ubiquitination (Ub)/NF-κB pathway has been identified to contribute to compensatory hypertrophic growth.433 FAK plays a key role in further proceeding the intracellular signals after integrin activation.434,435 Moreover, melusin, a muscle-specific integrin β1-interacting protein, is important in protecting cardiac hypertrophy.436,437 ILK also emerges as a crucial player in mechanotransduction by integrins.438,439. The gene discussed is ILK; the disease is cardiac hypertrophy.