ICAM2 and infection: Integrins αLβ2 (bound to intercellular adhesion molecule [ICAM]-1), αMβ2 (bound to ICAM-2), and α4β1 (bound to vascular cell-adhesion molecule [VCAM]-1) are activated, slowing the rolling of leukocytes.86 As leukocytes stop in the vascular endothelium, active integrin αLβ2 and αMβ2 induce leukocyte spreading and crawling toward infection.89 Leukocytes that reach the site of infection cross the vascular endothelium and enter infected tissue with the participation of integrin α6β1, thereby mediating the inflammatory response.86,89