Integrin β7 expressed in leukocytes is regarded as an important receptor that binds to MAdCAM-1 and induces homing of leukocytes to gut-associated lymphoid tissue.332 Integrin β7 pairs with other integrin α subunits, including α4 and αE,332 in which α4β7 affects the progression of NASH to liver fibrosis.332–334 At first, researchers focused only on the role of integrin β7 in NASH-induced liver fibrosis. This evidence concerns the gene MADCAM1 and Hepatic fibrosis.