DICER1 and viral infectious disease: A canonical Dicer protein contains a helicase domain, a PAZ domain, a domain of unknown function (DUF283), two RNase III domains, and a dsRNA binding domain.3 Dicer plays a vital role in cellular homeostasis and fighting virus infections.4 The Drosophila encodes two Dicers annotated as Dicer-1 and Dicer-2.