The PIEZO protein family are mechano-sensitive calcium channels first described in 2010.4 The MC/PIEZO2 channel unit modulates mechanical alloknesis under pathological conditions, as the loss of MC or the genetic ablation of PIEZO2 channels is associated with enhanced alloknesis in a murine dry skin model.5 Hence, in physiological states, tactile skin stimulation is perceived as light touch due to modulation of inhibitory spinal interneurons by input from MC/PIEZO2 expressing Aβ-LTMRs. This evidence concerns the gene PIEZO2 and Dry skin.