In a previous report, a homozygous mutation (R77H) in the SCGN gene was shown to be associated with early-onset colitis, and depletion of SCGN in mice impaired hormone secretion and increased inflammation susceptibility.29 These findings, in conjunction with our present report, demonstrate that decreased function of SCGN is associated with altered immune regulation in the intestine and in the brain. Here, SCGN is linked to colitis.