After comparing the hypoxia level between subtypes, we found that Mono and Macro_APOE/CTSZ subclusters were highly enriched in hypoxia‐high group, while Macro_FTL subcluster was mainly in hypoxia‐low group in both CRC‐MMRp and CRC‐MMRd datasets (Fig. 1C,D). Here, APOE is linked to colorectal carcinoma.