Immunofluorescent labeling demonstrated CD68/APOE‐positive and CD68/CTSZ‐positive cells localized and overlapped with GLUL‐positive cells (Fig. 7A,B; Fig. S10) and colocalized with FOXP3‐positive cells in nine CRC tissues sections (Fig. 7C,D; Fig. S11). Here, CTSZ is linked to colorectal carcinoma.