The results showed that solute carrier family 1 member 5 (SLC1A5) and solute carrier family 38 member 1 (SLC38A1), encoding enzymes involved in glutamine transports, were specifically upregulated in the tumor cells, while SLC1A3 and GLUL encoding enzymes that were involved in glutamate transports and glutamine synthetase were downregulated in tumor cells compared with Macro_APOE/CTSZ, in LC and CRC (Fig. S7f). This evidence concerns the gene APOE and laryngotracheoesophageal cleft.