In the subtypes, Macro_APOE/CTSZ was found to have a higher value in glutamate‐to‐glutamine and glutamate input transport metabolic flux (Fig. 2E,F), which was then confirmed by the observation of accumulated glutamine in Macro_APOE/CTSZ from CRC (Fig. 2G,H) and LC (Fig. S3d). Here, CTSZ is linked to colorectal carcinoma.