CTSZ and colorectal carcinoma: Fluorescence colocalization analysis showed that both Pearson's correlation coefficiency and overlap coefficiency were over 0.80 between APOE/CTSZ and GLUL, and over 0.70 between APOE/CTSZ and FOXP3 (Fig. S10h,i, Table S6), further supporting the potential crosstalk between these two dysfunctional cell populations to promote immunosuppression in malignant CRC.