Analysis of DEGs revealed that known immunosuppressive markers (such as APOE, CTSZ, SEPP1, MRC1, and CD163) were highly expressed in Macro_APOE/CTSZ compared with other myeloid subclusters in CRC‐MMRp (Fig. 3F), CRC‐MMRp, LC1, and LC2, respectively (Fig. S6a–c). The gene discussed is APOE; the disease is colorectal carcinoma.