The result showed that the gene expression of SLC3A1 and GLUL were highly expressed in Macro_APOE/CTSZ compared with other cell types in CRC and LC, and were upregulated in macrophage derived from tumor than normal tissues in CRC (Fig. 4A–D; Fig. S7b,c). Here, CTSZ is linked to laryngotracheoesophageal cleft.