Notably, MED samples showed a similar epithelial cell content as in EBUS samples though with a stronger expression of markers of the tumor microenvironment (TME) (CDH5, PTPRC aka CD45, and ACTA-2) (Fig. 2B) which, on the contrary, were absent in pure epithelial LNmets (EBUS samples). The gene discussed is CDH5; the disease is neoplasm.