Although an immunohistochemistry (IHC) analysis of LNmets to measure PD-L1, PD-1 and T cell markers was not feasible due to limited amount of samples, we showed in primary NSCLC tumors that a higher level of miR-455-5p was associated with decreased PD-L1 expression and increase in CD8 + T cell infiltration, in line with our hypotheses. The gene discussed is CD274; the disease is non-small cell lung carcinoma.