Importantly, we unveiled that the miR-455-5p/PD-L1 axis regulates the chemotherapy response of NSCLC cells, hallmarks metastases with active IFN-γ response pathway (an inducer of PD-L1 expression [34]), and impacts T cells viability and relative abundances in TME (Fig. 7H). This evidence concerns the gene IFNG and non-small cell lung carcinoma.