IFNG and silicosis: Then we used PD-1 blocking antibody or IgG combine with PBS, tuberculosis antigens library (ESAT-6, CFP-10, TB 7.7) or PHA to stimulate the peripheral blood of patients with silicosis, and found blockading the PD-1 pathway can significantly restore IFN-γ expression of tuberculosis antigen-specific specific cells (Fig. 3b).