PPARGC1A and gastric cancer: In GC tissues and GC cell lines, PPARGC1A expression was upregulated and associated with metastasis, invasion, and induce apoptosis of GC cells [63].  Rs8192678 SNV is the most well-studied variant of the PPARC1A, which substitutes glycine with serine at amino acid position 482 in exon 8.