For AD vs controls, we detected among others very high enrichment for TNF-α via NF-κB, IL-2/STAT5 and IL-6/JAK/STAT3 signalling and; for PV vs controls we detected among others high enrichment for TNF-α via NF-κB and PI3K/AKT/mTOR signalling (Fig. 1D). This evidence concerns the gene STAT3 and Alzheimer disease.