Histomorphologic correlates of certain driver alterations have been previously identified, such as giant-cell morphology in IDHwt glioblastomas harboring TP53 mutation, and epithelioid morphology in high grade gliomas harboring BRAF mutations; however, given the heterogeneity of infiltrating gliomas, and particularly in IDHwt astrocytomas/glioblastomas, these morphologic correlates as assessed by human pathologists have relatively poor predictive utility32–37. This evidence concerns the gene TP53 and central nervous system cancer.