Importantly, the perirhinal cortex and the transentorhinal regions are among the first to deposit tau pathology in AD (Braak and Braak, 1991), and regional accumulation of tau in the temporal lobes as measured by tau PET is correlated with atrophy of the perirhinal cortex (Sone et al., 2017). The gene discussed is MAPT; the disease is Alzheimer disease.